mergeStates {snapCGH} | R Documentation |
mergeStates
takes the output of a segementation algorithm in
the form of a SegList
and iteratively merges the
states with means closer than a supplied threshold.
mergeStates(segList, MergeType = 1, pv.thres=0.0001, ansari.sign=0.01, minDiff = 0.25)
segList |
Object of class SegList .
|
MergeType |
Select either 1 or 2. 1 uses a new merging algorithm developed by Hanni Willenbrock and Jane Fridlyand. |
pv.thres |
Significance threshold for Wilcoxon test for level merging. Used when MergeType = 1. |
ansari.sign |
Significance threshold for Ansari-Bradley test. Used when MergeType = 1. |
minDiff |
The states whose predicted values are less than minDiff apart are merged into one state and all the predicited values are recomputed. Used when MergeType = 2. |
This function is intended to reduce effect of the possible small magnitude technological artifacts on the structure determination.
A SegList
object is returned with the merged states
stored in the pred
list.
Jane Fridlyand
Application of Hidden Markov Models to the analysis of the array CGH data, Fridlyand et.al., JMVA, 2004
SegList
,
runHomHMM
,
runGLAD
,
runDNAcopy