BScore {RNAither} | R Documentation |
Normalization with BScores (see References).
BScore(header, dataset, listOfArgs)
header |
the header of a dataset file generated with generateDatasetFile |
dataset |
an R data frame generated with generateDatasetFile |
listOfArgs |
a list containing:
- a character string specifying the column whose values will be used for normalization - a flag specifying whether controls should be excluded for the computation of the median polish (1) or not (0) |
A list containing:
header |
The new header (with an added entry about the normalization procedure in the comments) |
dataset |
The new dataset with normalized values. The old values are saved in an extra column of the dataset with the suffix ".old" |
C. Brideau, B. Gunter, B. Pikounis, and A. Liaw. Improved statistical methods for hit selection in high-throughput screening. J Biomol Screen, 8:634-647, 2003
data(exampleHeader, package="RNAither") data(exampleDataset, package="RNAither") normres <- BScore(header, dataset, list("SigIntensity", 0)) newheader <- normres[[1]] newdataset <- normres[[2]]