Krogan complexes {apComplex}R Documentation

Krogan data complex estimates

Description

Affiliation matrices with rows corresponding to proteins and columns corresponding to complexes.

Usage

data(MBMEcKrogan)

Details

These are the results from an analysis of the AP-MS data (Krogan et al., 2004). These estimates were constructed using findComplexes with a sensitivity parameter of .75, specificity of .99, and Beta=-0.2 for externally derived similarity measure based on Gene Ontology cellular component annotation (see Scholtens and Gentleman (2004)).

MBMEcHMSPCI contains 82 multi-bait-multi-edge complex estimates.

Source

Scholtens D and Gentleman R. Making sense of high-throughput protein-protein interaction data. Statistical Applications in Genetics and Molecular Biology 3, Article 39 (2004).

Scholtens D, Vidal M, and Gentleman R. Local modeling of global interactome networks. Bioinformatics 21, 3548-3557 (2005).

References

High-Definition Macromolecular Composition of Yeast RNA-Processing Complexes; Molecular Cell, Vol 13, 225-239, 30 January 2004

Examples

data(MBMEcKrogan)
MBMEcKrogan[1:4,1:4]


[Package apComplex version 2.8.0 Index]